
陈小川,男,重庆市人,博士,副教授,硕士生导师。毕业于美国亚利桑那大学(University of Arizona),现任职于西南大学动物科学技术学院,兼任“动物种质创制与智能畜牧”团队秘书。入选重庆市“英才计划”,兼任中国畜牧兽医学会动物生理生化分会理事、重庆市生物化学与分子生物学会理事。
近年来主要以家畜为模式动物,长期聚焦遗传育种、代谢生理及智慧畜牧的交叉研究。主持国家自然科学基金、重庆市自然科学基金及省级产学研合作项目等课题10项;以第一作者或通讯作者在Journal of Physiology、Journal of Endocrinology、American Journal of Physiology-Endocrinology and Metabolism、Frontiers in Veterinary Science、Animals等国际权威期刊发表SCI论文10余篇;获授权专利3项、软件著作权2项。
团队依托“重庆市草食家畜重点实验室”等科研平台,融合基因编辑、分子标记、人工智能等前沿技术,系统解析家畜生长发育与代谢调控机制,并通过“产学研”一体化模式,在动物疫病快速检测、宠物精准营养、畜产品加工等领域实现研发转化和产业应用。
一、学习工作经历
2020.07至今 西南大学 动物科学技术学院 副教授、硕导
2012.10-2020.07 西南大学 动物科技学院 历任讲师、副教授、硕导
2009.06-2012.05 美国亚利桑那大学 动物科学专业 博士
2007.09-2009.05 美国亚利桑那大学 动物科学专业 硕士
2003.09-2007.06 西南大学 水产养殖专业 农学学士
二、研究方向及成果
主持科研项目
2025,山羊智能高效生产及重要呼吸道疫病防控技术研发与应用,重庆市科学技术局技术创新与应用发展重点专项
2025,AI+可溯源生猪精细化自动屠宰关键技术研究(子课题),中山市科学技术局重大科技专项
2022-2024,腾力素Tonisity对仔猪生长性能的影响研究,横向项目
2022-2023,基于多模型视觉识别的畜牧养殖的人工智能平台与大数据服务(子课题),荣昌高新区特色载体专项资金
2016-2019,持续高浓度去甲肾上腺素对胎羊胰岛素分泌的影响和机制研究,国家自然科学基金
2015-2017,长期高浓度去甲肾上腺素对绵羊胎儿胰岛素分泌调控的影响,重庆市科委前沿与创新
2014-2016,中央高校基本科研业务费
2013-2017,西南大学博士基金
参与科研项目
2024,肉羊种质资源创制和绿色高效养殖技术集成,重庆市农委重点项目
2024,乳酸对瘤胃上皮细胞的损伤机制研究,重庆市教委联合基金项目
2023,肉用山羊基因组选择参考群体的构建,国家重点研发计划子课题
2016-2020,乳酸菌SL001对AD模型小鼠胆固醇代谢及Aβ生成的影响及作用机制研究,国家自然科学基金
2016-2020,温和型热应激下胰岛素信号系统在公猪睾丸支持细胞乳酸生成中的分子机制,国家自然科学基金
2013-2015,草食动物种质创新与健康养殖,重庆市科委
代表性论文
1)龚常亮,靳奥龙,赵永聚,陈小川*.早期补充等渗蛋白溶液对哺乳仔猪生长性能、空肠发育及转录组变化的影响[J].畜牧兽医学报,1-13[2025-09].
2)Changliang Gong, Zhuohang Hao, Xinyi Liao, Robert J. Collier, Yao Xiao, Yongju Zhao, and Xiaochuan Chen*. Isotonic Protein Solution Supplementation Enhances Growth Performance, Intestinal Immunity, and Beneficial Microbiota in Suckling Piglets. Vet. Sci. 2025, 12, 715.
3)Changliang Gong, Huihui Song, Zhuohang Hao, Zhengyi Zhang, Nanjian Luo, and Xiaochuan Chen*. CTCF Represses CIB2 to Balance Proliferation and Differentiation of Goat Myogenic Satellite Cells via Integrin α7β1–PI3K/AKT Axis. Cells 2025, 14, 1199.
4)Ran Zhang, Bingpeng Yao, Rui Li, Sean W. Limesand, Yongju Zhao, and Xiaochuan Chen*. Chronic Epinephrine-Induced Endoplasmic Reticulum and Oxidative Stress Impairs Pancreatic β-Cells Function and Fate. International Journal of Molecular Sciences. 2024; 25, no. 13: 7029.
5)Huihui Song, Zhuohang Hao, Hehan Feng, Rui Li, Ran Zhang, Sean W. Limesand, Yongju Zhao, Xiaochuan Chen*. The insulin resistance and dyslipidemia in low birth weight goat kids. Frontiers in Veterinary Science. Mar 2024.
6)Liu T, Li R, Luo N, Lou P, Limesand SW, Yang Y, Zhao Y, Chen X*. Hepatic Lipid Accumulation and Dysregulation Associate with Enhanced Reactive Oxygen Species and Pro-Inflammatory Cytokine in Low-Birth-Weight Goats. Animals (Basel). 2022 Mar 18;12(6):766.
7)Rui Li, Huichai Huang, Sean W. Limesand, and Xiaochuan Chen*. Pancreatic Islets Exhibit Dysregulated Adaptation of Insulin Secretion after Chronic Epinephrine Exposure. Current Issues in Molecular Biology. 2021. 43, no. 1: 240-250.
8)Luo N, Wang J, Hu Y, Zhao Z, Zhao Y, Chen X*. Cold and heat climatic variations reduce indigenous goat birth weight and enhance pre-weaning mortality in subtropical monsoon region of China. Trop Anim Health Prod. 2020 May;52(3):1385-1394.
9)Camacho LE, Chen X, Hay WW Jr, Limesand SW. Enhanced insulin secretion and insulin sensitivity in young lambs with placental insufficiency-induced intrauterine growth restriction. Am J Physiol Regul Integr Comp Physiol. 2017 Aug 1;313(2):R101-R109.
10)Chen X, Kelly AC, Yates DT, Macko AR, Lynch RM, Limesand SW. Islet adaptations in fetal sheep persist following chronic exposure to high norepinephrine. J Endocrinology. 2017 Feb;232(2):285-295.
11)Macko AR, Yates DT, Chen X, Shelton LA, Kelly AC, Davis MA, Camacho LE, Anderson MJ, Limesand SW. Adrenal Demedullation and Oxygen Supplementation Independently Increase Glucose-Stimulated Insulin Concentrations in Fetal Sheep With Intrauterine Growth Restriction. Endocrinology. 2016 May;157(5):2104-15.
12)Chen X (陈小川), Green AS, Macko AR, Yates DT, Kelly AC, Limesand SW*. Enhanced insulin secretion responsiveness and islet adrenergic desensitization after chronic norepinephrine suppression is discontinued in fetal sheep. Am J Physiol Endocrinol Metab. 2014 Jan 1;306(1):E58-64.
13)Macko AR, Yates DT, Chen X, Green AS, Kelly AC, Brown LD, Limesand SW*. Elevated plasma norepinephrine inhibits insulin secretion, but adrenergic blockade reveals enhanced β-cell responsiveness in an ovine model of placental insufficiency at 0.7 of gestation. J Dev Orig Health Dis. 2013 Oct 1;4(5).
14)Yates DT, Macko AR, Chen X, Green AS, Kelly AC, Anderson MJ, Fowden AL, Limesand SW*. Hypoxaemia-induced catecholamine secretion from adrenal chromaffin cells inhibits glucose-stimulated hyperinsulinaemia in fetal sheep. The Journal of Physiology. 2012: 590(Pt 21):5439-47.
15)Yates DT, Macko AR, Nearing M, Chen X, Rhoads RP, Limesand SW*. Developmental programming in response to intrauterine growth restriction impairs myoblast function and skeletal muscle metabolism. Journal of Pregnancy. 2012:631038.
16)Chen X, Rozance PJ, Hay WW Jr, Limesand SW*. Insulin-like Growth Factor and Fibroblast Growth Factor Expression Profiles in Growth Restricted Fetal Sheep Pancreas. Experimental Biology and Medicine. 2012: 237(5):524-9.
17)Green AS, Macko AR, Rozance PJ, Yates DT, Chen X (陈小川), Hay WW Jr, Limesand SW*. Characterization of glucose-insulin responsiveness and impact of fetal number and gender on insulin response in the sheep fetus. American Journal of Physiology Endocrinology and Metabolism. 2011: 300(5), E817-823.
18)Chen X, Fahy AL, Green AS, Anderson MJ, Rhoads Jr RP, Limesand SW*. β2-Adrenergic Receptor Desensitization in Perirenal Adipose Tissue in Fetuses and Lambs with Placental Insufficiency-induced Intrauterine Growth Restriction. The Journal of Physiology. 2010: 588(Pt 18):3539-49.
19)Leos RA, Anderson MJ, Chen X, Pugmire J, Anderson KA, Limesand SW*. Chronic exposure to elevated norepinephrine suppresses insulin secretion in fetal sheep with placental insufficiency and intrauterine growth restriction. American Journal of Physiology Endocrinology and Metabolism. 2010: 298, E770-778.
20)Zheng K, Chen X, Li Y. Molecular Cloning, Sequence Analysis, and Tissue Expression of Insulin-like Growth Factor-I from Chinese sucker Myxocyprinus asiaticus Bleeker, J, Chinese Journal of Zoology, 2007, 42(2): 39-45. [Chinese].
专利
无死角监控的猪舍,授权公告号:CN 218483527 U
能够测猪体重的猪舍,授权公告号:CN 217958206 U
家畜造瘘用手术台,授权公告号:CN 111067657 A
软件著作权
智能化养殖图像识别监测管理平台,登记号:2023SR1050330
基于跟踪识别的智能化养殖行为监管系统,登记号:2023SR1697374
三、社会兼职
2017.09-至今,中国畜牧兽医学会动物生理生化分会,理事会理事
2015.12-至今,重庆市生物化学与分子生物学会,理事会理事
2025,International Journal of Molecular Sciences,客座编辑,Special Issue "Endocrine and Metabolic Regulation in Fetal Development Research"
2020-至今,重庆市巫溪县凤凰镇祥和山羊合作社,科技特派员
2018-2020,重庆市巫溪县红池坝镇九坪村,科技特派员
2014-2016,重庆市奉节县鑫鼎农业有限公司,科技特派员
四、学生培养
教学课程
动物生物化学、动物生理学、高级生物化学、高级生理学
重庆市线线下混合式一流课程
指导学生创新训练项目
2022-2023,方雨萌、宋泳锜、谢佳恒、邵子芮
2017-2021,杨丁凡、王琦、武嘉远
2015-2018,施磊、代琴芳、郑璐
2013-2016,王小巧、汤琦、牟烨
研究生招生
动物科学专业
动物遗传育种与繁殖(专业代码:090501);研究方向:动物生殖调控(代码:02)
五、联系方式
电子信箱: ans@swu.edu.cn
通讯地址:重庆市北碚区天生路2号西南大学动物科学技术学院 400715